. 2022; 39(3): 178-187 | DOI: 10.4274/tjh.galenos.2021.2021.0349 | |||
Küçük B-Hücreli Lenfomalarda Ek İmmünohistokimyasal Belirteçlerin Ayırıcı Tanıdaki Yeri: Bir Olgu-Kontrol ÇalışmasıHale Kıvrak1, Seher Yüksel1, Can Ateş2, Mustafa Merter3, Gülşah Kaygusuz1, Muhit Özcan4, Işınsu Kuzu11Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey2Aksaray University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Aksaray, Turkey; Ankara University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey 3Fırat University Faculty of Medicine, Department of Hematology, Elazığ, Turkey; Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey 4Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey Amaç: Küçük B-hücreli lenfomaların (SBCL) klinik ve patolojik ayırıcı tanısı halen tartışmalıdır ve örtüşen morfolojileri, fenotipleri ve plazma hücresine farklılaşmaları nedeni ile zorluk yaratabilir. Bu çalışmada plazma hücre farklılaşması gösteren farklı lokalizasyonlardaki SBCL’lerde, immün reseptör translokasyonu ilişkili protein 1 (IRTA1), myeloid hücre farklılaşma antijeni (MNDA), lenfoid güçlendirici bağlama faktörü-1 (LEF1) ve stathmin 1 (STMN1) belirteçlerinin ekspresyonu araştırılmıştır. Relevance of Additional Immunohistochemical Markers in the Differential Diagnosis of Small B-Cell Lymphomas: A Case-Control StudyHale Kıvrak1, Seher Yüksel1, Can Ateş2, Mustafa Merter3, Gülşah Kaygusuz1, Muhit Özcan4, Işınsu Kuzu11Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey2Aksaray University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Aksaray, Turkey; Ankara University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey 3Fırat University Faculty of Medicine, Department of Hematology, Elazığ, Turkey; Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey 4Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey Objective: Clinical and pathological differential diagnosis of small B-cell lymphomas (SBCLs) is still controversial and may be difficult due to their overlapping morphology, phenotype, and differentiation to plasma cells. We aimed to examine the expression of the immune receptor translocation-associated protein 1 (IRTA1), myeloid cell nuclear differentiation antigen (MNDA), lymphoid enhancer-binding factor-1 (LEF1), and stathmin 1 (STMN1) markers in SBCL cases involving different sites that may have plasma cell differentiation. Hale Kıvrak, Seher Yüksel, Can Ateş, Mustafa Merter, Gülşah Kaygusuz, Muhit Özcan, Işınsu Kuzu. Relevance of Additional Immunohistochemical Markers in the Differential Diagnosis of Small B-Cell Lymphomas: A Case-Control Study. . 2022; 39(3): 178-187 Sorumlu Yazar: Hale Kıvrak, Türkiye |
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