. 2009; 26(3): 114-117 | |||
Siprofloksasin: demir yüklenmesi için yeni bir terapötik ajan mı?Mitra Elmi1, Parvaneh Rahimi-moghaddam1, Khosrou Abdi2, Mehdi Shafiee-ardestani2, Massoud Mahmoudian11Razi Institute For Drug Research, Tehran, Iran; Department Of Pharmacology, College Of Medicine, Iran University Of Medical Sciences, Tehran, Iran2Department Of Medicinal Chemistry, College Of Pharmacy, Tehran University Of Medical Sciences, Tehran, Iran AMAÇ: Talasemi majör, karaciğer, kalp ve diğer organlarda demir yüklenmesiyle sonuçlanan, çoklu kan transfüzyonları gerektiren hematolojik hastalıklardan biridir. Güncel demir şelasyon tedavisi, intravenöz (IV) defroksamin ve oral deferasiroks ve deferipron uygulamasını içermektedir. Bu şelatörlerin etkili olmalarına karşın, birçok yan etkileri bulunmaktadır. Bu çalışmada, iyi oral absorbsiyonlu siprofloksasinin demir bağlayıcı etkileri araştırılmıştır. Ciprofloxacin: a novel therapeutic agent for iron overload?Mitra Elmi1, Parvaneh Rahimi-moghaddam1, Khosrou Abdi2, Mehdi Shafiee-ardestani2, Massoud Mahmoudian11Razi Institute For Drug Research, Tehran, Iran; Department Of Pharmacology, College Of Medicine, Iran University Of Medical Sciences, Tehran, Iran2Department Of Medicinal Chemistry, College Of Pharmacy, Tehran University Of Medical Sciences, Tehran, Iran OBJECTIVE: Major thalassemia is one of the hematological diseases requiring multiple blood transfusions, which results in iron overload in the liver, heart and other organs. Current iron chelation therapy consists of intravenous (IV) deferoxamine and oral deferasirox and deferiprone. Although these chelators are effective, many side effects are reported. In the present study, the iron-chelating effect of ciprofloxacin with good oral absorption was investigated. Mitra Elmi, Parvaneh Rahimi-moghaddam, Khosrou Abdi, Mehdi Shafiee-ardestani, Massoud Mahmoudian. Ciprofloxacin: a novel therapeutic agent for iron overload?. . 2009; 26(3): 114-117 Sorumlu Yazar: Massoud Mahmoudian, Iran |
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