. 2019; 36(3): 178-185 | DOI: 10.4274/tjh.galenos.2019.2018.0420 | |||
Multipl Myelomda Lokal Kemik İliği Renin-Anjiyotensin Sisteminin RolüBülent Saka1, Müge Sayitoğlu2, Zülal İstemihan1, Mehmet Akif Karan1, Sebile Nilgün Erten1, Öner Doğan3, Uğur Özbek2, Sema Genç4, Cemil Taşçıoğlu1, Sevgi Kalayoğlu Beşışık11İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey2İstanbul University, Aziz Sancar Institute of Experimental Research, Department of Genetics, İstanbul, Turkey 3İstanbul University, İstanbul Faculty of Medicine, Department of Pathology, İstanbul, Turkey 4İstanbul University, İstanbul Faculty of Medicine, Department of Biochemistry, İstanbul, Turkey Amaç: Anjiyotensin II, bazı tümörlerde tip 1 reseptörleri (AGTR1) yoluyla bir büyüme promotörü veya anjiyojenik faktör olarak görev yapar. Bu çalışmada, multipl myelomda (MM) kemik iliği AGTR1 ekspresyonunu ve bunun anjiyogenez ve prognostik faktörlerin düzenlenmesi ile ilişkisini incelemekteyiz. The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple MyelomaBülent Saka1, Müge Sayitoğlu2, Zülal İstemihan1, Mehmet Akif Karan1, Sebile Nilgün Erten1, Öner Doğan3, Uğur Özbek2, Sema Genç4, Cemil Taşçıoğlu1, Sevgi Kalayoğlu Beşışık11İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey2İstanbul University, Aziz Sancar Institute of Experimental Research, Department of Genetics, İstanbul, Turkey 3İstanbul University, İstanbul Faculty of Medicine, Department of Pathology, İstanbul, Turkey 4İstanbul University, İstanbul Faculty of Medicine, Department of Biochemistry, İstanbul, Turkey Objective: Angiotensin II promotes growth and angiogenesis via type 1 receptors (AGTR1) in certain tumors. In this study, we examine the bone marrow AGTR1 expression in multiple myeloma (MM) and its relationship with the regulation of angiogenesis and prognostic factors. Bülent Saka, Müge Sayitoğlu, Zülal İstemihan, Mehmet Akif Karan, Sebile Nilgün Erten, Öner Doğan, Uğur Özbek, Sema Genç, Cemil Taşçıoğlu, Sevgi Kalayoğlu Beşışık. The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma. . 2019; 36(3): 178-185 Sorumlu Yazar: Bülent Saka, Türkiye |
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