. 2017; 34(2): 143-150 | DOI: 10.4274/tjh.2016.0007 | |||
Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic LeukemiaBurcu Yazıcıoğlu1, Zühre Kaya1, Sezen Güntekin Ergün2, Ferda Perçin2, Ülker Koçak1, İdil Yenicesu1, Türkiz Gürsel11Gazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey2Gazi University Faculty of Medicine, Department of Genetics, Ankara, Turkey Objective: High-dose methotrexate (HD-MTX) is widely used in the consolidation phase of childhood acute lymphoblastic leukemia (ALL), but the roles that polymorphisms in folate-related genes (FRGs) play in HD-MTX toxicity and prognosis in children with ALL are not understood. The aims of this study were to investigate the frequencies of polymorphisms in the genes for thymidylate synthase (TS), methionine synthase reductase (MTRR), and methylene tetrahydrofolate reductase (MTHFR) in Turkish children with ALL and to assess associations between these polymorphisms and HD-MTXrelated toxicity and leukemia prognosis in this patient group. Folat İlişkili Gen Polimorfizmlerinin Akut Lenfoblastik Lösemili Türk Çocuklarında Yüksek Doz Metotreksat İlişkili Toksisite ve Prognoz Üzerine EtkisiBurcu Yazıcıoğlu1, Zühre Kaya1, Sezen Güntekin Ergün2, Ferda Perçin2, Ülker Koçak1, İdil Yenicesu1, Türkiz Gürsel11Gazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey2Gazi University Faculty of Medicine, Department of Genetics, Ankara, Turkey Amaç: Yüksek doz metotreksat (YD-MTX) çocukluk çağı akut lenfoblastik lösemi (ALL) tedavisinin yoğunlaştırma fazında yaygın olarak kullanılmaktadır, ancak ALL’li çocuklarda YD-MTX’in toksisite ve prognozunda rol oynayan folat ilişkili genlerdeki (FİG) polimorfizmlerin rolü iyi bilinmemektedir. Bu çalışmanın amacı; ALL’li Türk çocuklarındaki timidilat sentaz (TS), metionin sentaz redüktaz (MTRR) ve metilen tetrahidrofolat redüktazı (MTHFR) kodlayan genlerdeki polimorfizm sıklığını araştırmak, bu hasta grubunda polimorfizmler ile YD-MTX’e bağlı toksisite ve lösemi prognozu arasındaki ilişkiyi değerlendirmektir. Burcu Yazıcıoğlu, Zühre Kaya, Sezen Güntekin Ergün, Ferda Perçin, Ülker Koçak, İdil Yenicesu, Türkiz Gürsel. Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic Leukemia. . 2017; 34(2): 143-150 Corresponding Author: Zühre Kaya, Türkiye |
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