. 2016; 33(1): 8-14 | DOI: 10.4274/tjh.2014.0190 | |||
Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl PeriodHakan Savlı1, Ramis Ufuk Akkoyunlu1, Naci Çine1, Daniil F. Gluzman2, Michael P. Zavelevich2, Lilia M. Sklyarenko2, Stella V. Koval2, Deniz Sünnetçi11Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey2National Academy of Sciences of Ukraine, R.E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv, Ukraine INTRODUCTION: Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies in the post-Chernobyl period. Çernobil Sonrası Ukraynalı Lösemi ve Lenfoma Hastalarında Değişken NF-κB1, NF-κB2 ve Rel Gen DüzeyleriHakan Savlı1, Ramis Ufuk Akkoyunlu1, Naci Çine1, Daniil F. Gluzman2, Michael P. Zavelevich2, Lilia M. Sklyarenko2, Stella V. Koval2, Deniz Sünnetçi11Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey2National Academy of Sciences of Ukraine, R.E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv, Ukraine GİRİŞ ve AMAÇ: Nükleer faktör kappa B (NF-κB), kanserde önemli bir transkripsiyon faktörü olup aktivasyonu anjiyogenez, tümör gelişimi ve metastazın birçok basamağında görülmektedir. Spesifik NF-κB gen ağları, lökomogenez ve radyasyon maruziyeti arasındaki ilişki halen belirsizdir. Çalışmamızda Çernobil sonrası hematolojik kanserlerde NF-κB1, NF-κB2 ve Rel genlerinin ekspresyon düzeylerini incelemeyi amaçladık. Hakan Savlı, Ramis Ufuk Akkoyunlu, Naci Çine, Daniil F. Gluzman, Michael P. Zavelevich, Lilia M. Sklyarenko, Stella V. Koval, Deniz Sünnetçi. Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period. . 2016; 33(1): 8-14 Corresponding Author: Deniz Sünnetçi, Türkiye |
|