. 2010; 27(2): 82-90 | DOI: 10.5152/tjh.2010.05 | |||
Enhanced platelet adhesion in essential thrombocythemia after in vitro activationAndreas C. Eriksson1, Kourosh Lotfi2, Per A. Whiss11Division Of Drug Research/pharmacology, Department Of Medical And Health Sciences, Linköping University, Sweden And Department Of Hematology, University Hospital, Linköping, Sweden2Division Of Drug Research/clinical Pharmacology, Department Of Medical And Health Sciences, Linköping University, Sweden OBJECTIVE: Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by elevated platelet counts and increased risk of thrombosis. Ex vivo data suggest increased platelet reactivity in agreement with the increased thrombosis risk, while in vitro tests often detect decreased platelet activity. The present study aimed to investigate adhesion of ET-platelets in vitro, which is an aspect of platelet function that has been addressed in only a few studies on ET patients. In vitro aktivasyon sonrası esansiyel trombositemide yüksek platelet adezyonuAndreas C. Eriksson1, Kourosh Lotfi2, Per A. Whiss11Division Of Drug Research/pharmacology, Department Of Medical And Health Sciences, Linköping University, Sweden And Department Of Hematology, University Hospital, Linköping, Sweden2Division Of Drug Research/clinical Pharmacology, Department Of Medical And Health Sciences, Linköping University, Sweden AMAÇ: Esansiyel trombositemi (ET) platelet sayısının artması ve yüksek tromboz riski ile karakterize kronik bir myeloproliferatif bozukluktur. Ex vivo veriler tromboz riskine uygun olarak artan platelet reaktivitesini öne sürerken in vitro testler sıklıkla platelet aktivitesinde azalma tespit etmektedir. Bu çalışmanın amacı ET-hastalarında az sayıda çalışmaya dahil edilmiş bir platelet fonksiyonu konusu olan ET-plateletleri adezyonunun in vitro incelenmesidir. Andreas C. Eriksson, Kourosh Lotfi, Per A. Whiss. Enhanced platelet adhesion in essential thrombocythemia after in vitro activation. . 2010; 27(2): 82-90 Corresponding Author: Andreas C. Eriksson, Sweden |
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