. 2017; 34(2): 137-142 | DOI: 10.4274/tjh.2016.0092 | |||
Gonadotoxic Effects of Nilotinib in Chronic Myeloid Leukemia Treatment Dose in a Mouse ModelGüldane Seval1, Sinan Özkavukçu2, Murat Seval3, Meltem Aylı11Ufuk University Faculty of Medicine, Department of Hematology, Ankara, Turkey2Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Center of Assisted Reproduction, Ankara, Turkey 3Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey Objective: Tyrosine kinase inhibitors may have deleterious effects on spermatogenesis or folliculogenesis, resulting in male or female subfertility. The aim of this study is to determine the effect of nilotinib, which is used routinely to treat chronic myeloid leukemia, on spermatogenesis and folliculogenesis by using histopathological parameters. Kronik Miyeloid Lösemi Tedavi Dozunda Nilotinib’in Gonadotoksik Etkilerinin Fare Modelinde GösterilmesiGüldane Seval1, Sinan Özkavukçu2, Murat Seval3, Meltem Aylı11Ufuk University Faculty of Medicine, Department of Hematology, Ankara, Turkey2Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Center of Assisted Reproduction, Ankara, Turkey 3Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey Amaç: Tirozin kinaz inhibitörlerinin; potansiyel gonadotoksisite ve döllenme üzerindeki olası etkileri hakkında kesin veriler bulunmamaktadır. Bu çalışmanın amacı sağlıklı fare modelinde nilotinib tedavisinin fertilite üzerine etkilerini araştırmaktır Güldane Seval, Sinan Özkavukçu, Murat Seval, Meltem Aylı. Gonadotoxic Effects of Nilotinib in Chronic Myeloid Leukemia Treatment Dose in a Mouse Model. . 2017; 34(2): 137-142 Corresponding Author: Güldane Seval, Türkiye |
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