. 2017; 34(3): 233-238 | DOI: 10.4274/tjh.2016.0397 | |||
Clinical Outcomes Related to the Use of Bendamustine Therapy for Multiple Myeloma Patients Relapsed/Refractory to Immunomodulatory Drugs and Proteasome InhibitorsFevzi Fırat Yalnız1, Nihan Akkoç2, Ayşe Salihoğlu1, M. Cem Ar1, Şeniz Öngören1, A. Emre Eşkazan1, Teoman Soysal1, Yıldız Aydın11İstanbul University Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey2İstanbul University Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey Objective: Multiple myeloma patients who are relapsed or refractory to both proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs) have been reported to have poor outcomes. Bendamustine has been reported to have an antitumor effect in newly diagnosed as well as relapsed/refractory multiple myeloma (RRMM). The aim of this retrospective study was to evaluate the efficacy of bendamustine therapy in heavily pretreated MM patients who were refractory to PIs and IMiDs. İmmünomodülatuvar İlaçlar ve Proteazom İnhibitörlerine Dirençli Multipl Miyelom Hastalarında Bendamustin Tedavi EtkinliğiFevzi Fırat Yalnız1, Nihan Akkoç2, Ayşe Salihoğlu1, M. Cem Ar1, Şeniz Öngören1, A. Emre Eşkazan1, Teoman Soysal1, Yıldız Aydın11İstanbul University Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Turkey2İstanbul University Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey Amaç: Proteazom inhibitörleri (PIs) ve immünomodülatuvar ilaçlar (IMiDs) içeren tedavi rejimlerine relaps refrakter multipl miyelom (RRMM) hastalarının prognozu oldukça kötüdür. Bendamustin yeni tanı almış ve RRMM hastalarında etkinliği bildirilmiş bir ajandır. Bu retrospektif çalışmanın amacı, öncesinde yoğun tedavi almış, PIs ve IMiDs tedavilerine RRMM hastalarında bendamustin tedavi etkinliğinin ortaya konmasıdır. Fevzi Fırat Yalnız, Nihan Akkoç, Ayşe Salihoğlu, M. Cem Ar, Şeniz Öngören, A. Emre Eşkazan, Teoman Soysal, Yıldız Aydın. Clinical Outcomes Related to the Use of Bendamustine Therapy for Multiple Myeloma Patients Relapsed/Refractory to Immunomodulatory Drugs and Proteasome Inhibitors. . 2017; 34(3): 233-238 Corresponding Author: Fevzi Fırat Yalnız, Türkiye |
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