. 2017; 34(1): 64-71 | DOI: 10.4274/tjh.2016.0049 | |||
Generation of Platelet Microparticles after Cryopreservation of Apheresis Platelet Concentrates Contributes to Hemostatic Activityİbrahim Eker1, Soner Yılmaz2, Rıza Aytaç Çetinkaya3, Aysel Pekel4, Aytekin Ünlü5, Orhan Gürsel1, Sebahattin Yılmaz3, Ferit Avcu6, Uğur Muşabak4, Ahmet Pekoğlu3, Zerrin Ertaş7, Cengizhan Açıkel8, Nazif Zeybek5, Ahmet Emin Kürekçi1, İsmail Yaşar Avcı91Division of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey2Blood Training Center and Blood Bank of Gulhane Military Medical Academy, Ankara, Turkey 3Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Infectious Disease Istanbul, Turkey 4Division of Immunulogy and Allergy, Gulhane Military Medical Academy, Ankara, Turkey 5Department of General Surgery, Gulhane Military Medical Academy, Ankara, Turkey 6Division of Hematology, Memorial Hospital, Ankara, Turkey 7Division of Hematology, Gulhane Military Medical Academy, Ankara, Turkey 8Division of Biostatistics. Gulhane Military Medical Academy, Ankara, Turkey 9Department of Infectious Disease abd Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey Objective: In the last decade, substantial evidence has accumulated about the use of cryopreserved platelet concentrates, especially in trauma. However, little reference has been made in these studies to the morphological and functional changes of platelets. Recently platelets have been shown to be activated by cryopreservation processes and to undergo procoagulant membrane changes resulting in the generation of platelet-derived microparticles (PMPs), platelet degranulation, and release of platelet-derived growth factors (PDGFs). We assessed the viabilities and the PMP and PDGF levels of cryopreserved platelets, and their relation with thrombin generation. Aferez Trombosit Konsantrelerinin Kriyoprezervasyonu Sonrası Ortaya Çıkan Trombosit Kaynaklı Mikropartiküllerin Hemostatik Aktivite ile İlişkisiİbrahim Eker1, Soner Yılmaz2, Rıza Aytaç Çetinkaya3, Aysel Pekel4, Aytekin Ünlü5, Orhan Gürsel1, Sebahattin Yılmaz3, Ferit Avcu6, Uğur Muşabak4, Ahmet Pekoğlu3, Zerrin Ertaş7, Cengizhan Açıkel8, Nazif Zeybek5, Ahmet Emin Kürekçi1, İsmail Yaşar Avcı91Division of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey2Blood Training Center and Blood Bank of Gulhane Military Medical Academy, Ankara, Turkey 3Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Infectious Disease Istanbul, Turkey 4Division of Immunulogy and Allergy, Gulhane Military Medical Academy, Ankara, Turkey 5Department of General Surgery, Gulhane Military Medical Academy, Ankara, Turkey 6Division of Hematology, Memorial Hospital, Ankara, Turkey 7Division of Hematology, Gulhane Military Medical Academy, Ankara, Turkey 8Division of Biostatistics. Gulhane Military Medical Academy, Ankara, Turkey 9Department of Infectious Disease abd Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey Amaç: Son on yıl içerisinde, dondurulup saklanan trombositlerin özellikle travma hastalarında kullanımı ile ilgili önemli bir bilgi birikimi oluşmuştur. Bununla birlikte bu çalışmalarda trombositlerin morfolojik ve fonksiyonel değişikliklerinden çok az bahsedilmektedir. Son zamanlarda dondurulup saklanan trombositlerin aktive olarak trombosit kaynaklı mikropartikül (TKM) oluşumu ve trombosit kaynaklı büyüme faktörü (TKBF) salınımı ile sonuçlanan prokoagulan membran değişiklikleri olduğu saptanmıştır. Çalışmamızda dondurulup saklanan trombositlerin canlılıkları, TKM ve TKBF düzeyleri incelenerek trombin olumuyla ilişkileri değerlendirildi. İbrahim Eker, Soner Yılmaz, Rıza Aytaç Çetinkaya, Aysel Pekel, Aytekin Ünlü, Orhan Gürsel, Sebahattin Yılmaz, Ferit Avcu, Uğur Muşabak, Ahmet Pekoğlu, Zerrin Ertaş, Cengizhan Açıkel, Nazif Zeybek, Ahmet Emin Kürekçi, İsmail Yaşar Avcı. Generation of Platelet Microparticles after Cryopreservation of Apheresis Platelet Concentrates Contributes to Hemostatic Activity. . 2017; 34(1): 64-71 Corresponding Author: Soner Yılmaz, Türkiye |
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