. 2018; 35(1): 42-48 | DOI: 10.4274/tjh.2016.0498 | |||
The Effect of Bone Marrow Mesenchymal Stem Cells on the Granulocytic Differentiation of HL-60 CellsHossein Nikkhah1, Elham Safarzadeh2, Karim Shamsasenjan1, Mehdi Yousefi2, Parisa Lotfinejad3, Mehdi Talebi1, Mozhde Mohammadian4, Farhoud Golafshan5, Ali Akbar Movassaghpour11Tabriz University Faculty of Medicine, Hematology and Oncology Research Center, Tabriz, Iran2Tabriz University Faculty of Medicine, Drug Applied Research Center, Tabriz, Iran; Tabriz University Faculty of Medicine, Department of Immunology, Tabriz, Iran 3Tabriz University Faculty of Medicine, Hematology and Oncology Research Center, Tabriz, Iran; Tabriz University Faculty of Medicine, Department of Immunology, Tabriz, Iran 4Mazandaran University Faculty of Medicine, Amol Faculty of Paramedical Sciences, Sari, Iran 5Hamline University Faculty of Medicine, Department of Biology, Minnesota, USA Objective: Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types. They control the process of hematopoiesis by secreting regulatory cytokines and growth factors and by the expression of important cell adhesion molecules for cell-to-cell interactions. This investigation was intended to examine the effect of bone marrow (BM)-derived MSCs on the differentiation of HL-60 cells according to morphological evaluation, flow cytometry analysis, and gene expression profile. Kemik İliği Mezankimal Hücrelerinin HL-60 Hücrelerindeki Granülositik Farklılaşması Üzerine EtkisiHossein Nikkhah1, Elham Safarzadeh2, Karim Shamsasenjan1, Mehdi Yousefi2, Parisa Lotfinejad3, Mehdi Talebi1, Mozhde Mohammadian4, Farhoud Golafshan5, Ali Akbar Movassaghpour11Tabriz University Faculty of Medicine, Hematology and Oncology Research Center, Tabriz, Iran2Tabriz University Faculty of Medicine, Drug Applied Research Center, Tabriz, Iran; Tabriz University Faculty of Medicine, Department of Immunology, Tabriz, Iran 3Tabriz University Faculty of Medicine, Hematology and Oncology Research Center, Tabriz, Iran; Tabriz University Faculty of Medicine, Department of Immunology, Tabriz, Iran 4Mazandaran University Faculty of Medicine, Amol Faculty of Paramedical Sciences, Sari, Iran 5Hamline University Faculty of Medicine, Department of Biology, Minnesota, USA Amaç: Mezankimal kök hücreler (MKH) birçok hücre tipine göre farklılaşabilen multipotent stromal hücrelerdir. Hematopoez sürecini düzenleyici sitokinler ve büyüme faktörleri salınımı ile ve hücreler arası etkileşim için önemli hücresel adezyon moleküllerinin ifadesi yoluyla kontrol ederler. Bu çalışma da kemik iliği (Kİ) kaynaklı MKH HL-60 hücrelerinin farklılaşması üzerine etkisini morfolojik değerlendirme, akım sitometri ve gen ifade analizi yöntemleriyle araştırılması amaçlanmıştır. Hossein Nikkhah, Elham Safarzadeh, Karim Shamsasenjan, Mehdi Yousefi, Parisa Lotfinejad, Mehdi Talebi, Mozhde Mohammadian, Farhoud Golafshan, Ali Akbar Movassaghpour. The Effect of Bone Marrow Mesenchymal Stem Cells on the Granulocytic Differentiation of HL-60 Cells. . 2018; 35(1): 42-48 Corresponding Author: Ali Akbar Movassaghpour, Iran |
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