. 2019; 36(3): 186-192 | DOI: 10.4274/tjh.galenos.2019.2019.0090 | |||
The Use of Allogeneic Mesenchymal Stem Cells in Childhood Steroid-Resistant Acute Graft-Versus-Host Disease: A Retrospective Study of a Single-Center ExperienceCeyhun Bozkurt1, Erdal Karaöz2, Başak Adaklı Aksoy1, Selime Aydoğdu3, Tunç Fışgın31İstinye University Faculty of Medicine, Department of Pediatrics, İstanbul, Turkey; Altınbaş University Faculty of Medicine, Bahçelievler Medical Park Hospital Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey2İstinye University Faculty of Medicine, Department of Histology-Embryology, İstanbul, Turkey; İstinye University Faculty of Medicine, Stem Cell and Tissue Engineering Research and Application Center, İstanbul, Turkey; Liv Hospital, Regenerative Medicine, Stem Cell Production Center, İstanbul, Turkey 3Altınbaş University Faculty of Medicine, Bahçelievler Medical Park Hospital Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey Objective: Objective: Steroid-resistant acute graft-versus-host disease (srAGVHD) is the most important cause of morbidity and mortality after allogeneic stem cell transplantation. There are several treatment methods available, including mesenchymal stem cell (MSC) application. The aim of this study was to evaluate the results of MSC therapy performed in children with srAGVHD. Çocukluk Çağı Steroid Dirençli Akut Graft Versus-Host Hastalığında Allojenik Mezenkimal Kök Hücre Kullanımı: Retrospektif Bir Çalışma, Tek Merkez DeneyimiCeyhun Bozkurt1, Erdal Karaöz2, Başak Adaklı Aksoy1, Selime Aydoğdu3, Tunç Fışgın31İstinye University Faculty of Medicine, Department of Pediatrics, İstanbul, Turkey; Altınbaş University Faculty of Medicine, Bahçelievler Medical Park Hospital Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey2İstinye University Faculty of Medicine, Department of Histology-Embryology, İstanbul, Turkey; İstinye University Faculty of Medicine, Stem Cell and Tissue Engineering Research and Application Center, İstanbul, Turkey; Liv Hospital, Regenerative Medicine, Stem Cell Production Center, İstanbul, Turkey 3Altınbaş University Faculty of Medicine, Bahçelievler Medical Park Hospital Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey Amaç: Amaç: Steroid dirençli akut graft versus host hastalığı (sdAGVHH), allojenik kök hücre naklinden sonra en önemli morbidite ve mortalite nedenidir. Mezenkimal kök hücre (MKH) uygulaması da dahil olmak üzere çeşitli tedavi yöntemleri mevcuttur. Bu çalışmanın amacı, sdAGVHH’li çocuklarda yapılan MKH tedavisi sonuçlarını değerlendirmektir. Ceyhun Bozkurt, Erdal Karaöz, Başak Adaklı Aksoy, Selime Aydoğdu, Tunç Fışgın. The Use of Allogeneic Mesenchymal Stem Cells in Childhood Steroid-Resistant Acute Graft-Versus-Host Disease: A Retrospective Study of a Single-Center Experience. . 2019; 36(3): 186-192 Corresponding Author: Ceyhun Bozkurt, Türkiye |
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