. 2020; 37(2): 84-90 | DOI: 10.4274/tjh.galenos.2019.2019.0177 | |||
Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort StudyMüfide Okay1, Tuncay Aslan1, Evren Özdemir2, Ayşegül Üner3, Arzu Sağlam3, Elif Güngör4, Ayşe Uysal5, Nevin Alayvaz Aslan6, Esra Yıldızhan7, Abdullah Ağıt8, Mehmet Sinan Dal9, Serdal Korkmaz10, Sinem Namdaroğlu11, Serdar Sivgin12, Gülsüm Akgün Cağlıyan131Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey2Medicana International Ankara Hospital, Clinic of Medical Oncology, Ankara, Turkey 3Hacettepe University Faculty of Medicine, Department of Pathology, Ankara, Turkey 4Trakya University Faculty of Medicine, Department of Internal Medicine, Edirne, Turkey 5University of Health Sciences, Trabzon Kanuni Training and Research Hospital, Division of Hematology, Trabzon, Turkey 6Ondokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey 7Erciyes University Faculty of Medicine, Department of Hematology, Kayseri, Turkey 8Ankara Numune Training and Research Hospital, Division of Hematology, Ankara, Turkey 9University of Health Sciences, Ankara Oncology Training and Research Hospital, Clinic of Hematology and BMT Unit, Ankara, Turkey 10Kayseri Training and Research Hospital, Division of Hematology, Kayseri, Turkey 11University of Health Sciences, İzmir, Turkey 12Acıbadem Kayseri Hospital, Kayseri, Turkey 13Denizli State Hospital, Division of Hematology, Denizli, Turkey Objective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Türkiye’de Splenik Marjinal Zon Lenfoma: Hepatit C Virüs Yerine Hepatit B Virüsünün Etiyolojik ve Olası Prognostik Faktör Oluşu-Çok Merkezli Kohort ÇalışmasıMüfide Okay1, Tuncay Aslan1, Evren Özdemir2, Ayşegül Üner3, Arzu Sağlam3, Elif Güngör4, Ayşe Uysal5, Nevin Alayvaz Aslan6, Esra Yıldızhan7, Abdullah Ağıt8, Mehmet Sinan Dal9, Serdal Korkmaz10, Sinem Namdaroğlu11, Serdar Sivgin12, Gülsüm Akgün Cağlıyan131Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey2Medicana International Ankara Hospital, Clinic of Medical Oncology, Ankara, Turkey 3Hacettepe University Faculty of Medicine, Department of Pathology, Ankara, Turkey 4Trakya University Faculty of Medicine, Department of Internal Medicine, Edirne, Turkey 5University of Health Sciences, Trabzon Kanuni Training and Research Hospital, Division of Hematology, Trabzon, Turkey 6Ondokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey 7Erciyes University Faculty of Medicine, Department of Hematology, Kayseri, Turkey 8Ankara Numune Training and Research Hospital, Division of Hematology, Ankara, Turkey 9University of Health Sciences, Ankara Oncology Training and Research Hospital, Clinic of Hematology and BMT Unit, Ankara, Turkey 10Kayseri Training and Research Hospital, Division of Hematology, Kayseri, Turkey 11University of Health Sciences, İzmir, Turkey 12Acıbadem Kayseri Hospital, Kayseri, Turkey 13Denizli State Hospital, Division of Hematology, Denizli, Turkey Amaç: Splenik marjinal zon lenfoma’yı da (SMZL) içeren ekstranodal marjinal zon lenfomaların patogenezinde, kronik antijenik stimülasyon sorumlu olan mekanizmadır. Bazı coğrafik bölgelerde SMZL hastalarında kronik hepatit C sıklıkla gözlenir. Fakat bu çalışmalar sıklıkla kuzey Amerika ve Avrupa’dandır. Diğer ülkelerden veriler sınırlıdır. Bu çalışma ile Türkiye’deki SMZL hastalarının hepatit serolojisi durumları ve tedavi yöntemlerinin ortaya konulması amaçlanmıştır Müfide Okay, Tuncay Aslan, Evren Özdemir, Ayşegül Üner, Arzu Sağlam, Elif Güngör, Ayşe Uysal, Nevin Alayvaz Aslan, Esra Yıldızhan, Abdullah Ağıt, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroğlu, Serdar Sivgin, Gülsüm Akgün Cağlıyan. Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study. . 2020; 37(2): 84-90 Corresponding Author: Müfide Okay |
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