. 2018; 27(3): 0-0

I-131 mIBG SCINTIGRAPHY CURIE VERSUS SIOPEN SCORING: PROGNOSTIC VALUE IN STAGE 4 NEUROBLASTOMA

Saima Riaz1, Humayun Bashir1, Saadiya Javed Khan2, Abid Qazi3
1Department of Nuclear medicine Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
2Department of Pediatric Oncology Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
3Department of Surgery, Doctors Hospital, Canal Bank, Johar Town Lahore

INTRODUCTION: I-131 mIBG scan semi-quantitative analysis with Modified Curie and the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) scoring systems is helpful in the evaluation of extent of disease and has prognostic impact in stage 4 neuroblastoma.
METHODS: Retrospective, cross-sectional analysis of baseline I-131 mIBG scans in 21 patients with stage 4 or 4S neuroblastoma diagnosed between January 2007 and December 2015. All scans were assessed for Curie and SIOPEN scores. Distribution of scores was evaluated for risk factors i.e. age at diagnosis (>18 months) and early relapse (within 12 months). A curie score <2 and SIOPEN score <4 at diagnosis were correlated for event-free (EFS) and overall (OS) survival.
RESULTS: Data set was comprised of 12(57%) males and 9(43%) females. Patients with age > 18 months (n=9) at diagnosis or early relapse (n=9) had higher Curie (Mean 5+7.5SD, p=0.004) and SIOPEN (Mean 5.2+10.8SD, p=0.02) scores.
Patients with a Curie score <2 and a SIOPEN score of <4 had better EFS and OS than patients with higher scores. Curie: 5-year EFS = 79% versus 33% (p 0.03); 5-year OS= 56% versus 36% (p 0.01). SIOPEN: 5-year EFS = 70% versus 17% (p 0.002); 5-year OS= 58% versus 17% (p 0.04). No statistically significant difference was found between the survival predictive value of two scoring systems (Hazard ratio 2.38, 95% CI: 0.33-16.9, p = 0.38).

DISCUSSION AND CONCLUSION: I-131 mIBG Curie and SIOPEN scores have prognostication value in stage 4 neuroblastoma and should be routinely applied. Higher scores predict unfavorable prognosis.

Keywords: I-131 mIBG scan, Neuroblastoma, Curie scores, SIOPEN scores


Saima Riaz, Humayun Bashir, Saadiya Javed Khan, Abid Qazi. I-131 mIBG SCINTIGRAPHY CURIE VERSUS SIOPEN SCORING: PROGNOSTIC VALUE IN STAGE 4 NEUROBLASTOMA. . 2018; 27(3): 0-0

Corresponding Author: Saima Riaz, Pakistan


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