. 9999; 0: 0-0

The effect of low dose ketamine on the need for morphine in patients with multiple trauma

Farhad Heydari1, Reza Azarian2, babak masoumi3, Alireza Abootalebi Ghahnavieh4
1Farhad Heydari
2Reza Azarian
3Babak Masoumi
4Alireza Abootalebi Ghahnavieh

Aim: Previous studies revealed that Low dose ketamine promptly and satisfactorily resolved pain. The aim of this study was to compare the analgesic effects of morphine with placebo to a combination of morphine with ketamine for patients with multiple trauma in the emergency department (ED).
Methods: This randomized, controlled, double-blinded clinical trial was conducted in the ED of two university educational hospitals. Patients between 16 to 50 years with a severe acute pain defined as a visual analog scale (VAS) score of at least 70 (between 0 and 100) were enrolled. Patients were randomly assigned to receive intravenous morphine (0.1 mg/kg) with placebo or morphine (0.05 mg/kg) with low dose ketamine (0.3 mg/kg) for pain control. The pain intensity was asked before and 10, 20, 30, and 60 minutes, after the intervention, and probable side effects were recorded. Efficient analgesia was defined as a VAS score not exceeding 30. The primary outcome was VAS at 30 minutes.
Results: Seventy patients were enrolled in the study. The pain intensity decreased significantly in both groups after 30 minutes of the intervention. There was no significant difference between the mean VAS of the two groups before and after intervention. Morphine consumption was significantly lower in the ketamine group versus the morphine group (p=0.01). There was no significant difference between the two groups in terms of complications (p>0.05).
Conclusion: Low-dose ketamine in combination with morphine significantly reduced the need for an additional dose of morphine without increasing complications to morphine alone.

Keywords: Analgesic, Emergency Department, Ketamine, Morphine, Multiple Trauma, Pain


Farhad Heydari, Reza Azarian, babak masoumi, Alireza Abootalebi Ghahnavieh. The effect of low dose ketamine on the need for morphine in patients with multiple trauma. . 9999; 0: 0-0

Corresponding Author: Farhad Heydari, Iran


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