. 9999; 0: 0-0

Evaluation of the Effect of Inhalation Ipratropium Use on Pupil Dilatation in Rats

Hatice Şeyma Akça, Büşra ihtiyar, Kamil Kokulu, Abdullah Algın, Serdar Özdemir, Serkan Emre Eroğlu, Gökhan Aksel
Department of Emergency Medicine, University of Health Sciences, Ümraniye Education and Research Hospital, Istanbul, Turkey

Introduction

The aim of this study was to investigate the effect of inhaled ipratropium on pupil diameter when applied directly onto the eye in a closed environment.

Materials and Methods

A total of 14, 8-week-old and 350-g weight Sprague dawley rats were obtained from Yeditepe University Laboratory of Experimental Animals for research. At constant temperature (22 ± 3 ºC) and 12-hour light / dark cycle, the rats had access to standard feed and water. 7 rats were exposed to ipratropium while 7 rats were given saline nebular. Pupil diameters and pupillary-orbital diameter ratios were compared before exposure and 2 hours after exposure to the drug.
Pupil diameters and pupillary-orbital diameter ratios measured before and 2 hours after inhalation ipratropium administration were compared in the computer environment after 4288x2848 pixel magnification.
Results
There was no significant difference in pupil / orbital diameter ratios in either the right or the left eyes after treatment compared to baseline values (p >0.05, for both).
There was no significant difference in Delta rates. The numerical data fitted the normal distribution.

Conclusion
In our study, no significant difference in diameter changes were determined that would advocate that we should be more careful in the case of anisocoria development in patients receiving ipropropium treatment and to perform a detailed neurological examination and request neurology consultation as soon as possible. Anisocoria or changes in pupil diameters that we may encounter in both pupils may not always be associated with drug use.

Keywords: pupil diameter, nebulized ipratropium, anisocoria


Hatice Şeyma Akça, Büşra ihtiyar, Kamil Kokulu, Abdullah Algın, Serdar Özdemir, Serkan Emre Eroğlu, Gökhan Aksel. Evaluation of the Effect of Inhalation Ipratropium Use on Pupil Dilatation in Rats. . 9999; 0: 0-0

Corresponding Author: Hatice Şeyma Akça, Türkiye


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