|
. 2009; 15(1): 39-44 | |||
Beyin ölümü hastalarında aminoasit solüsyonlarına metabolik ve termojenik yanıtİlkin Çankayalı, Kubilay Demirağ, Seden Kocabaş, Ali Reşat MoralEge Üniversitesi Tıp Fakültesi, Anesteziyoloji Ve Reanimasyon Anabilim Dalı, İzmiAMAÇ: Aminoasit infüzyonu ile enerji tüketimi ve termojenezdeki artış arasında güçlü bir ilinti vardır. Bu çalışmada, yoğun bakımda beyin ölümü tanısı almış hastalarda termojenez ve enerji tüketimindeki artışa aminoasit solüsyonlarının etkisi araştırıldı. Thermogenic and metabolic response to amino acid solution in brain-dead patientsİlkin Çankayalı, Kubilay Demirağ, Seden Kocabaş, Ali Reşat MoralDepartment Of Anesthesiology And Intensive Care Unit, Ege University Faculty Of Medicine, Izmir, TurkeyBACKGROUND: There is a strong correlation between amino acid infusion and increase in energy expenditure and thermogenesis. In this study, the effects of amino acid solutions on thermogenesis and energy expenditure were investigated in intensive care patients who were diagnosed as brain death. METHODS: Twenty-six brain-dead patients were included in the study. The patients received a 4 h infusion of standard amino acid solution. Energy expenditure was measured by indirect calorimetric method. ANOVA and Bonferroni tests were used for statistical analysis. RESULTS: The predicted energy expenditure (PEE) values were higher than the resting energy expenditure (REE) values in 24 patients. The mean REE/PEE value in all patients indicated that there was a 29% decrease in REE when compared to PEE. Body temperature and energy expenditure values were not increased during the parenteral infusion of amino acid solutions. There was no statistically significant difference between mean metabolic measurements and basal values at any time interval during the study period. CONCLUSION: We conclude that the stimulatory effect of amino acid solution on energy expenditure and thermogenesis is abolished in brain-dead patients. This result may indicate a possible central pathway responsible for the increase in energy expenditure and thermogenesis. Keywords: Amino acid, brain death; energy expenditure; thermogenesis.İlkin Çankayalı, Kubilay Demirağ, Seden Kocabaş, Ali Reşat Moral. Thermogenic and metabolic response to amino acid solution in brain-dead patients. . 2009; 15(1): 39-44 Sorumlu Yazar: İlkin Çankayalı, Türkiye |
|