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. 2007; 13(4): 281-287 | |||
Ağır kafa travmalı hastalarda beyin omurilik sıvısı ve serum IGF-1 ve IGFBP-3 değerleriGalip Zihni Sanus1, Taner Tanrıverdi1, Abdurrahman Coşkun2, Hakan Hanımoğlu1, Merih Is3, Mustafa Uzan11İ.ü. Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul2Abant İzzet Baysal Üniversitesi, Biyokimya Anabilim Dalı, Düzce 3Abant İzzet Baysal Üniversitesi, Nöroşirürji Anabilim Dalı, Düzce AMAÇ: Bu çalışmanın amacı, insülin benzeri büyüme faktörü-1 (IGF-1) ve insülin-benzeri bağlama protein-3 (IGFBP-3) moleküllerinin ciddi kafa travması sonrası serumda ve beyin omurlik sıvısı’ndaki (BOS) seviyelerini ölçmek ve kontrol grubu ile karşılaştırmaktır. Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injuryGalip Zihni Sanus1, Taner Tanrıverdi1, Abdurrahman Coşkun2, Hakan Hanımoğlu1, Merih Is3, Mustafa Uzan11Department Of Neurosurgery, Istanbul University Cerrahpaşa Medical Faculty, Istanbul2Department Of Biochemistry, Medicine Faculty Of Abant Izzet Baysal University, Düzce, Turkey 3Department Of Neurosurgery, Medicine Faculty Of Abant Izzet Baysal University, Düzce, Turkey BACKGROUND: The aim of this study is to present time course of insulin like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in both cerebrospinal fluid (CSF) and serum of patients after severe head injury (SHI) and to compare with controls. METHODS: Our trauma and control groups included 11 consecutive patients with isolated SHI and 9 patients with hydrocephalus (one with normotensive and eight with hydrocephalus due to aqueduct stenosis), respectively. Both serum and cerebrospinal fluid levels of IGF-1 and IGFBP-3 were measured during post-traumatic days and we compared the levels with controls. RESULTS: Patients and controls showed undetectable levels of both IGF-1 and IGFBP-3 in their CSF. When considering serum levels, patients with SHI had always lower levels of both molecules than that of controls. CONCLUSION: Administration of IGF-1 during acute, as well as chronic phase of severe head trauma may provide beneficial effects and may decrease both mortality and morbidity in humans with SHI. Keywords: Brain trauma/drug therapy, IGF-1; IGFBP-3; immunohistochemistry/methods; neuroprotection; severe head injury.Galip Zihni Sanus, Taner Tanrıverdi, Abdurrahman Coşkun, Hakan Hanımoğlu, Merih Is, Mustafa Uzan. Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. . 2007; 13(4): 281-287 Sorumlu Yazar: Taner Tanrıverdi, Türkiye |
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