Ulus Travma Acil Cerrahi Derg. 2007; 13(4): 261-267 | |||
Sıçanlarda arteriyel oklüzyona bağlı akut mezenterik iskeminin erken tanısında diyagnostik peritoneal lavaj sıvısında pH ve potasyumDoğan Gönüllü1, Yücel Yankol2, Ferruh Işıman3, Ayşenur Akyıldız İğdem4, Osman Yücel1, Ferda Nihat Köksoy11Taksim Eğitim Ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İstanbul2İstanbul Memorial Hastanesi, Genel Cerrahi Kliniği, İstanbul 3Taksim Eğitim Ve Araştırma Hastanesi, Biokimya Laboratuvarı, İstanbul 4Taksim Eğitim Ve Araştırma Hastanesi, Patoloji Laboratuvarı, İstanbul İskeminin yarattığı asidoza eşlik eden pH düşmesi ve potasyum yükselmesi bilgileri, peritoneal lavaj sıvısında test edilerek, deneysel erken tanıya katkı sağlanması amaçlandı. pH value and potassium level of diagnostic peritoneal lavage fluid in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in ratsDoğan Gönüllü1, Yücel Yankol2, Ferruh Işıman3, Ayşenur Akyıldız İğdem4, Osman Yücel1, Ferda Nihat Köksoy11Department Of General Surgery, Taksim Training And Research Hospital, İstanbul, Turkey2Department Of General Surgery, Istanbul Memorial Hospital, Istanbul, Turkey 3Department Of Biochemistry, Taksim Training And Research Hospital, İstanbul, Turkey 4Department Of Pathology, Taksim Training And Research Hospital, İstanbul, Turkey BACKGROUND: In this experimental study we evaluated the pH and potassium changes of the peritoneal irrigation fluid in the early phase of mesenteric ischemia. METHODS: The Wistar albino rats were assigned randomly to 5 equal groups of 10 rats: sham operation, 30, 60, 120 and 180 minutes ischemia by arterial occlusion. We enregistred the ranges of pH and potassium in peritoneal irrigation fluid and serum pH. RESULTS: Lower pH and increased potassium levels in peritoneal irrigation fluid were observed in 30 and 60 min ischemia groups. In 120 and 180 ischemia groups the level of pH continued to be lower and potassium level increased gradually, the serum pH were markedly lower in these groups. Histological analysis showed a positive correlation between the intestinal injury and ischemia time. CONCLUSION: In contrast to sham group, increase in potassium and decrease in in pH levels in peritoneal irrigation fluid were seen in 30 and 60 min ischemia groups. The decrease of serum pH was enregistred after 120 min of ischemia. In early phase the measurement of potassium and pH in peritoneal irrigation fluid may be an early diagnostic tool for mesenteric ischemia. Keywords: Ischemia/diagnosis/pathology/physiopathology, peritoneal lavage, pH; potassium; rats, Wistar.Doğan Gönüllü, Yücel Yankol, Ferruh Işıman, Ayşenur Akyıldız İğdem, Osman Yücel, Ferda Nihat Köksoy. pH value and potassium level of diagnostic peritoneal lavage fluid in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in rats. Ulus Travma Acil Cerrahi Derg. 2007; 13(4): 261-267 Sorumlu Yazar: Doğan Gönüllü, Türkiye |
|