Correlates of Risk Factors in Arteriosclerosis Obliterans Confirmed by Angiographic by Angiographic and Operative Examination

ÇETİNARSLAN, Y.Berrin; KOMSUOĞLU, Baki; UZUN, Zerrin; KULAN, Kaan; ÖZCAN, Fahri

Y.Berrin ÇETİNARSLAN¹, Baki KOMSUOĞLU¹, Zerrin UZUN¹, Kaan KULAN¹, Fahri ÖZCAN¹

Lipid and lipoprotein levels as well as certain other risk factors were studied in 35 patients with arteriosclerosis obliterans (confirmed by angiographic and operative examination). Seventy-two asymptomatic normal subjects sevred as controls. The mean serum total cholesterol and triglyceride levels in control subjects were 168±31 mg/dl and 144±81 mg/dl respectively. In patients with arteriosclerosis obliterans, these values were 191±44 mg/dl, and 183±76 mg/dl. Significant differences existed in the mean serum total cholesterol and triglyceride levels between two groups. The mean LDL-cholesterol, Apo-B levels were significantly higher in patients than in controls. HDL-cholesterol and Apo-A1 levels were signifiantly lower in patients than in controls. Patients with arteriosclerosis obliterans were characterized as follows: 77 % were smokers, 37 % were hypertensive, 14 % were obese, and 5.7 % had diabetes. The HDL-C levels were significantly lower in controls who smoked than in non-smoking control subjects; this may indirectly explain the reduced HDL ratio in patients with obstructive peripheral vascular disease, most of whom were smokers.

Keywords:

Anjiyografik ve Operatif Muayene ile Belirlenen Arterioskleroz Obliterans ile Bazı Ateroskleroz Risk Faktörlerinin İlişkisi

Y.Berrin ÇETİNARSLAN¹, Baki KOMSUOĞLU¹, Zerrin UZUN¹, Kaan KULAN¹, Fahri ÖZCAN¹

Karadeniz Teknik Üniv. Tıp Fakültesi Farabi Hastanesi, Kardiyoloji ve Göğüs-Kalp-Damar Cerrahisi Bölümleri, Trabzon

Lipid ve lipoprotein seviyeleri ve diğer bazı risk faktörleri, anjiografik ve operatif muayene ile obliteratif aterosklerotik arteriopati saptanan 35 hastada incelendi. 72 asemptomatik normal kişi kontrol grubu olarak seçildi. Serum kolesterol ve trigliserid ortalama düzeyleri kontrol grubunda sırasıyla 168±31 mg/dl ve 144±81 mg/dl iken hasta grubunda 191±44 mg/dl ve 183±76 mg/dl olarak bulundu ve iki gruptan elde edilen bu ortalama değerler arasındaki farkın istatistik olarak anlamlı olduğu görüldü. Kontrol ve hasta grubunda ortalama serum HDL-kolesterol, LDL-Kolesterol, Apo-AI, Apo-B düzeyleri arasında istatistik olarak anlamlı fark bulundu. Arterioskleroz obliterans saptanan hastaların % 77'si sigara içiyordu, % 37'si hipertansif, % 14'ü obes ve % 5.7'si diabetikti. Serum HDL-kolesterol seviyeleri kontrol grubundaki sigara içenlerde içmeyenlere göre anlamlı şekilde daha düşüktü; bu, çoğu sigara içen arterioskleroz obliterans olan hastalarda azalmış HDL oranını açıklayabilir.

Anahtar Kelimeler:

Y.Berrin ÇETİNARSLAN, Baki KOMSUOĞLU, Zerrin UZUN, Kaan KULAN, Fahri ÖZCAN. Correlates of Risk Factors in Arteriosclerosis Obliterans Confirmed by Angiographic by Angiographic and Operative Examination. Turk Kardiyol Dern Ars. 1993; 21(3): 178-181