Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion

KIRILMAZ, Ata; ERİNÇ, Kürşad; KILIÇARSLAN, Fethi; DEMİRTAŞ, Ertan

Ata KIRILMAZ¹, Kürşad ERİNÇ², Fethi KILIÇARSLAN², Ertan DEMİRTAŞ²

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The frequency and the degree of fractionation of intraatrial recordings during atrial fibrillation (AF) have a correlation with the wavelengths and the size of the reentry pathways. We hypothesized that spectral ana lysis might help to explain the mechanism of antiarrhythmic drug- induced termination of AF. The frequency spectrum of monophas ic action potenti als recorded in the right atrium was ana lysed us ing Fast Fourier Transformatian (FFT). The maximal, minimal, first 5 peak frequencies and the width of frequency distribution within each 5 see segments were calculated before and after placebo (group C, n=7), ibut il ide 1.6±0.4 mg (group I, n= IO) or procainamide 1240±221 mg (group P, n= 10) infusion in 24 patients with AF. Age (66±9, 68±6 and 64±7), LA size (40±8, 44±5 and 46±4 mm) and LV EF (44± 11 , 43±7 and 40±11) were s imilar in group I, P and C, respectively (p>0.05). Ibutilide and procainamide decreased the peak AF frequency from 6.2±0.6 and 6.5±1.1 Hz to 4.3±0.3 and 4.5±0.8 Hz, respectively (p<0.00 1), whereas placebo had no effect on FFT. Ibutilide decreased the frequency of the peaks significantly within 30 see after each dose. In 3 patients in group I, AF terminated. Cardioverted patients tented to have a lower frequency at baseline than nonconverters (5.7±.3 vs. 6.4±.6 Hz). Ibutilide decreased the frequency of AF to 3.5±0.1 Hz before cardioversion. Conclusions: Fourier transformatian analysis of AF electrograms is a useful method for evaluation of the effect of drugs on atrial tissue. Ibutilide may decrease the frequency of AF to a critica! level before cardioversion.

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Atriya/ fibrilasyon (AF) esnasmda atriyum içi kayillanmn fraksinasyon derecesi ve frekans/ ree1ıtran yol/ann dalgaboyu ve büyüklüğü ile uyum gösterir. Atriyal fibri/asyo- 111111 ilaç ile sonianma mekanizmalaruu açıklamada spectra/ analizin yardm/Cl olabileceğini savunduk. Sağ atriyumdan kaydedilen monofaz ik aksiyon potansiyellerininfrekans spekturunw. /mil Fourier döniişiimii (FFT) ile incelendi. Atriyal fibrilasyonlu 24 lıastac/a en yüksek, en cliişiik ve ilk 5 tepe frekans/ ile frekans dağilmun/lı genişliği, plasebo (grup C, n=7), ibutilid 1.6±0.4 mg (grup 1, n=10) veya prokainamid 1240±221 mg (grup P, n=10) infüzyonu öncesi ve sonrası 5'er saniyelik zaman dilimleri lıalinc/e saptandı. Yaş (66±9, 68±6 ve 64±7), sol atrial çap (40±8, 44±5 ve 46±4 mm) ve sol ventrikiil EF (44±11, 43±7 ve 40±11) gruplar arasında farkli değildi (sıras1 ile grup 1, P ve C, p>0.05). 1butilid and prokainamid AF tepe frekansını sı rası ile 6.2 ±0.6 ve 6.5±1.1 Hz'den 4.3±0.3 ve 4.5±0.8 Hz'e indirdi (pAnahtar Kelimeler: Atriyal fibrilasyon, monofazik aksiyon potansiyeli, hızlı Fourier dönüşümü

Ata KIRILMAZ, Kürşad ERİNÇ, Fethi KILIÇARSLAN, Ertan DEMİRTAŞ. Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion. Turk Kardiyol Dern Ars. 2001; 29(8): 481-487

Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion

BAŞARILI KARDİYOVERSİYONU ÖNGÖRMEDE İBÜTİLİD VE PROKAİNAMİD VERİLMESİNİ TAKiBEN ATRİAL FİBRİLASYON İNTERVALLERİNİN "FOURIER" TRANSFORMASYONU ANALİZİ